Cranial Bone Regeneration with Collagen Type I and Polyvinylpyrrolidone (Fibroquel®) Combined with Hyaluronic Acid in Wistar Rats: Morphological Study

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Adolfo Soto-Domínguez; Gilberto Zatarain-Hernández; Rubén García-Garza; Lydia Enith Nava Rivera; María de los Ángeles Pietschmann-Santamaría; Enrique Díaz-Palomares; Edson Josue Pacheco-Herrera; Rodrigo Lozoya-Martínez; María de la Paz Holguin-Santana; Nadia Denys Betancourt-Martínez; Jair Millán Orozco & Javier Morán-Martínez


The purpose of this study was to evaluate by morphological methods, if a mixture of Fibroquel® and hyaluronic acid implanted in an animal model of cranial bone injury could promote bone regeneration. 12 Wistar rats were divided in three groups, control group, bone injury without treatment and bone injury with treatment. After experimental period, bone samples were taken and stained with H & E, Masson trichrome, PAS-D, immunohistochemistry with anti-PCNA monoclonal antibody and applied a semiquantitative morphometric method. Treatment group showed extensive areas of collagen fibers in contact with normal bone tissue, areas of normal histology, PAS positive material and less cellular proliferation. We demonstrated for the first time that a mixture of Fibroquel® and hyaluronic acid implanted in an animal model of cranial bone injury promotes bone regeneration.

KEY WORDS: Bone; Cranial; Regeneration; Collagen; Wistar Rat.

How to cite this article

SOTO-DOMÍNGUEZ, A.; ZATARAÍN-HERNÁNDEZ, G.; GARCÍA-GARZA, R.; NAVA-RIVERA, L. E.; PIETSCHMANN- SANTAMARÍA, M. A.; DÍAZ-PALOMARES, E.; PACHECO-HERRERA E. J.; LOZOYA-MARTÍNEZ, R.; HOLGUIN- SANTANA, M. P.; BETANCOURT-MARTÍNEZ, N. D.; MILLÁN-OROZCO, J. & MORÁN-MARTÍNEZ, J. Cranial bone regeneration with collagen type i and polyvinylpyrrolidone (Fibroquel®) combined with hyaluronic acid in wistar rats: morphological study. Int. J. Morphol., 39(3):816-822, 2021.