Expression and Distribution of Kallikrein-related Peptidases 5, 7, 8 and 10 in Normal Apocrine Gland of Canine Skin

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Pamela Ehrenfeld; Carlos D. Figueroa; Luis Molina; Tania Koning; Myriam Velasco; Felipe A. Bustamante-Barrientos & Alexander Ortloff


Apocrine glands are sweat glands that are located in the skin of the dog. Anal sac apocrine, circunanal apocrine, and mammary glands are considered modified apocrine structures, and there are about nine possible types of neoplasms and other tumors in the apocrine glands of the dog and cat, including cysts, adenoma, carcinoma, and adenocarcinoma. Thus, it is important to provide new markers to characterize these glands to improve the histopathological diagnosis. In this article, we describe the distribution of kallikrein- related peptidases 5, 7, 8, and 10 in the normal apocrine glands of the dog’s skin. These proteases have been shown to play a fundamental role in the homeostasis of the human skin barrier but have been scarcely studied in canine skin.

KEY WORDS: Kallikrein-related peptidases; KLKs; Apocrine gland; Dog.

How to cite this article

EHRENFELD, P.; FIGUEROA, C. D.; MOLINA, L.; KONING, T.; VELASCO, M.; BUSTAMANTE-BARRIENTOS, F. A. & ORTLOFF, A. Expression and distribution of kallikrein-related peptidases 5, 7, 8 and 10 in normal apocrine gland of canine skin. Int. J. Morphol., 41(1):210-215, 2023.