Cristian A. Ratiu; Ioana A. Ratiu; Viorel Miclaus; Mihai Pantor; Vasile Rus; Cristian O. Martonos; Radu Lacatus; Robert C. Purdoiu & Adrian F. Gal

The utility of metallic bio-medical implants in osseous or dental affections is irrefutable. The paper aims to test the tolerance of the bone marrow to titanium implants. Titanium implants were inserted in the femur of 11-months old rabbits. The implants penetrated the endosteum, half of their length getting into the haematogenous bone marrow. Seven days after the insertion we collected bone fragments containing the implant. The CT exam revealed a significant decrease in the density of the bone at the interface with the implant and a more discrete one aloof from the insertion area. The histologic exam after 7 days revealed osseous reparatory processes only in the endosteal area from where it expanded on the surface of the implant which was inside the marrow. The presence and intensity of the osseous reparatory processes after only seven days post-implant demonstrates that the marrow actively participates in bone regeneration and implants osseointegration.

KEY WORDS: Osseointegration; Titanium implant; Endosteum, Haematogenous bone marrow.

RATIU, C. A.; RATIU, I. A.; MICLAUS, V.; PANTOR, M.; RUS, V.; MARTONOS, C. O.; LACATUS, R.; PURDOIU, R. C. & GAL, A. F. The influence of haematogenous bone marrow on the early osseointegration of a titanium implant which penetrates the endosteum. Int. J. Morphol., 40(1):188-193, 2022.