The Morphology of Paca (Cuniculus paca) Testis with High Dose of Letrozole an Aromatase Inhibitor

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Luciana Senna Simões; Taís Harumi de Castro Sasahara; Phelipe Oliveira Favaron; Leonardo Martins Leal; Fabrício Singaretti de Oliveira; Paula Fratini; Trish Berger; Marcia Rita Fernandes Machado & Maria Angélica Miglino


The study reported the influence of the high and acute dose of Letrozole on the testis morphology in paca (Cuniculus paca), an aromatase inhibitor that reduces the endogenous estrogen, the essential hormone for spermatogenesis. Morphological changes were observed in seminiferous epithelium with germ cells with apoptotic characteristics and presence of vacuoles and nuclei in pycnose.

KEY WORDS: Gonadal; Toxic; Spermatogenesis.

How to cite this article

SIMÕES, L. S.; SASAHARA, T. H. C.; FAVARON, P. O.; LEAL, L. M.; OLIVEIRA, F. S.; FRATINI, P.; BERGER, T.; MA- CHADO, M. R. F. & MIGLINO, M. A. The morphology of paca (Cuniculus paca) testis with high dose of letrozole, an aromatase inhibitor. Int. J. Morphol., 38(6):1525-1527, 2020.