Antioxidant Activity of Selenium on Bisphenol-Induced Apoptosis and Testicular Toxicity of Albino Rats

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Mohamed Samir Ahmed Zaki; Mohamed A. Haidara; Mohammed Heitham; Abdalla Asim; Ehab El Sayed Massoud & Refaat A. Eid


Bisphenol A (BPA) is an industrial chemical widely used to make polycarbonate plastics for packaging and epoxy resins. This study sought to examine how selenium (Se) affects BPA toxicity in terms of albino rats’ histological structure, antioxidant enzymes and reproductive organs (seminiferous tubules). Twenty-four adult male rats were divided into four experimental groups: Group 1: Control; Group 2: Orally administered BPA; Group 3: Orally administered sodium selenite; Group 4: Treated daily with BPA followed by selenium (Se). All experiment done for 4 weeks. BPA exposure caused changes in the testicular histological structure, which consists apoptosis, and led to changes in several biochemical markers: Malondialdehyde, catalase, superoxide dismutase, and glutathione peroxidase. However, these BPA side effects may be ameliorated in rats treated with BPA-plus-Se. These protective effects of Se may attributable to its ability to remove potentially damaging oxidizing agents in living organisms. The results may confirm that Se countered the oxidant effects and increased the BPA-induced stress response in rats. So, Se promotes the healthy growth and development of mammals by protecting them from oxidative stress. As human are greatly exposed to BPA and it can accumulate in tissues, there is concern about human reproductive functions particularly for occupational workers exposed usually to greater levels of BPA. Thus, the use of BPA in multiple industries must be restricted and the inaccurate usage of plastic containers should be avoided to decrease the health hazards. Administration of Se may protect against the adverse effects of BPA on reproductive functions and structures.

KEY WORDS: Bisphenol A; Selenium; Testis; Biochemical enzymes; Histology; Ultrastructure; Statistical analysis.

How to cite this article

ZAKI, M. S. A.; HAIDARA, M. A.; HEITHAM, M.; ASIM, A.; MASSOUD, E. E. S. & EID, R. A. Antioxidant activity of selenium on bisphenol-induced apoptosis and testicular toxicity of albino rats. Int. J. Morphol., 38(6):1786-1796, 2020.