Aging Process Entrainment: Suprachiasmatic Nucleus and Pineal Gland

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Parménides Guadarrama-Ortiz; Ricardo Ramírez-Aguilar; Alejandro Madrid-Sánchez; Carlos Castillo-Rangel; Diana Carrasco-Alcántara & Raúl Aguilar-Roblero


The suprachiasmatic nucleus (SCN) is the main and major biological clock in mammals and is responsible for the synchronization of the pineal gland to the light/darkness cycle through a polysynaptic pathway. The neuroendocrine feedback loop effect is carried out by melatonin. This study was carried out to demonstrate that the pineal gland adjusts the sensibility to light in the suprachiasmatic nucleus. Wistar rats were allocated in 3 groups: Group A (sham pinalectomy, without light), group B (sham pinealectomy + light) and group C which underwent real pinalectomy + light. After the intervention the animals were slain to perform immunohistochemistry for c-Fos and cell counting by stereology technique. A 46.8% average reduction in c-Fos immunoreactive cells was achieved in-group C as compared with group B. The present work shows that sensibility to the light is modulate by the activity of the pineal gland.

KEY WORDS: Pinealectomy; c-Fos; Sham operation; Suprachiasmatic nucleus.

How to cite this article

GUADARRAMA-ORTIZ, P.; RAMÍREZ-AGUILAR, R.; MADRID-SÁNCHEZ, A.; CASTILLO-RANGEL, C.; CARRASCO- ALCÁNTARA, D. & AGUILAR-ROBLERO, R. Aging process entrainment: suprachiasmatic nucleus and pineal gland. Int. J. Morphol., 32(2):409-414, 2014.