Immunohistochemical Expression of Phosphatase and Tensin Homologue in Glioblastoma Multiforme and its Relationship to Survival

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Esteban F. Espinoza-García; Andrés Horlacher-Kunstmann & Francisco M. González-Vicuña


Glioblastoma multiforme is the most frequent glioma subtype in adults, with poor survival rate after diagnosis even applying the optimal treatment. Tumoural markers have been studied looking for good prognosis, being the phosphatase and tensin homologue controversial. Paraffined samples were used from Carlos Van Buren Hospital in Valparaíso, Chile, between 2010 and 2014. An immunohistochemical analysis was performed looking for phosphatase and tensing homologue expression, studying the intensity and expression pattern in astrocytes and epithelial cells, in addition to clinical data. Statistical analysis was performed using SPSS v20. It was studied the phosphatase and tensin homologue expression in 21 patients. In the study, 52,4 % presented low expression in astrocytic glial cell nuclei, with a survival mean of 14.2 months in comparison to 10.2 months in the high expression group (p=0.33). A very intense endothelial expression was found in tumoural tissue, in comparison to the tissue without tumor. A relation between nuclear expression in astrocytes and survival rate was found, although no statistically significant. The intense endothelial expression seen in tumoural tissue must be studied directly.

KEY WORDS: Brain neoplasms; Glioblastoma; Glioma; Immunohistochemistry; Survival.

How to cite this article

ESPINOZA-GARCÍA, E. F.; HORLACHER-KUNSTMANN, A. & GONZÁLEZ-VICUÑA, F. M. Immunohistochemical expression of phosphatase and tensin homologue in glioblastoma multiforme and its relationship to survival. Int. J. Morphol., 37(3):800-804, 2019.