Comparison Between Conventional Sutures with Ulmoplus® and without Ulmoplus® in the Incision Closure of Rabbit Skin (Oryctolagus cuniculus)

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Luis Espín; Bélgica Vásquez; Carolina Schencke; & Mariano del Sol


Considering the advances in research that relate honey therapeutic effects in wound healing process, the present investigation aimed to evaluate and com- pare qualitatively, through morphological analysis, the lo- cal tissue response between conventional suture with Ulmoplus ® and without Ulmoplus ® in the closure of the rabbit skin incision. We used 10 adult rabbits, divided into group S (suture) and group S + U (suture plus Ulmoplus®). An 10 mm long incision was made in the anterior region of the leg, passing through epidermis and dermis, until reaching the deep fascia that covered the anterior tibial muscle. Subsequently, only the S + U group was given Ulmoplus®. Then, in both groups, the incision was sutured with two intradermal points of polyglycolic acid (vicryl 2/0). After 10 days post incision, biopsies of the skin were taken and processed for observation in a light microscope. The study was carried out considering the recommendations of the Guide for the Care and Use of Laboratory Animals. Both groups had a closed incision at day 10 with microscopic characteristics of a proliferative phase. However, the S + U group showed a scar of shorter length and flatter appearance, whose epidermis was more organized and thinner, with differentiated basal cells. At the dermal level, wound contraction was observed, evidencing a smaller scar area. Ulmoplus®, as a coadjuvant in closing surgical wounds process using conventional suture is a good alternative, since it accelerates the healing process and allows better aesthetic results of the scar.

KEY WORDS: Rabbit; Incision; Suture; Healing, Ulmoplus®.

How to cite this article

ESPÍN, L.; VÁSQUEZ, B.; SCHENCKE, C. & DEL SOL, M. Comparison between conventional sutures with Ulmoplus® and without Ulmoplus® in the incision closure of rabbit skin (Oryctolagus cuniculus). Int. J. Morphol., 37(3):1073-1078, 2019.