Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure

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Amir Raoofi; Saeed Gharibian & Yousef Sadeghi


We have surveyed the motor changes in rats subjected to sciatic nerve axotomy. The rats were divided into two groups, each one consisting of ten animals, which underwent the following intervention: The first group (control): healthy rats without any injuries and experimental group: rats with injured sciatic nerve without treatment. at 12 weeks, the L4 and L5 spinal cord segments were removed. We evaluated nerve function using muscle electromyography (EMG) activity and sciatic function index (SFI) simultaneously with histological spinal cord analyses by stereological methods at 12 week. After nerve injury presented gross locomotor deficits at week 12. We also found that the volume of the anterior horn of spinal cord and total number of motor neurons were decreased after nerve axotomy (p<0.05). In conjunction, these results indicate that peripheral nerve injuries have more severe consequences on hind limb motor output.

KEY WORDS: Degenerative; Anterior horn of spinal cord; Stereology; Axotomy; Motor functional.

How to cite this article

RAOOFI, A.; GHARIBIAN, S. & SADEGHI, Y. Impairment induction by axotomy in motor functional and histological ante- rior horn of spinal cord structure. Int. J. Morphol., 37(3):1101-1106, 2019.