Moringa oleifera Impairs the Morphology and Functions of the Kidney in Adult Wistar Rats
DOI : http://dx.doi.org/10.4067/S0717-95022014000200016
Abdulazeez Adelaja Akinlolu; Olaide Kamal Ghazali; Oloduowo Mubarak Ameen; Seunayo Comfort Oyebanji; Gabriel Olaiya Omotoso & Bernard Ufuoma Enaibe
We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II IV received 250, 500 and 750 mg/kg bodyweight of methanolic extract of Moringa oleifera respectively for twenty one days. No behavioral anomalies were observed in rats of Groups I IV. Rats of Control Group I gained statistically significant increased bodyweight while rats of Groups II IV experienced non-significant decreased bodyweight during experimental procedure. (P0.05). No statistical significant differences (P0.05) were observed in the analyses of the relative weights of kidneys of rats of Groups I IV. Histological examinations showed normal cyto-architecture of the kidneys of rats of Group I while the Capsular spaces of the kidneys of rats of Groups II IV appeared wider than those of Group I. Statistical analyses showed significant higher levels (P0.05) of Alanine and Aspartate Transaminases, and serum urea in rats of Groups II IV in a non- dose-dependent manner when compared to rats of Group I. Our findings are consistent with the stated hypothesis.
KEY WORDS: Moringa oleifera; Toxicity profile; Kidney.
How to cite this article
AKINLOLU, A. A.; GHAZALI, O. K.; AMEEN, O. M.; OYEBANJI, S. C.; OMOTOSO, G. O. & ENAIBE, B. U. Moringa oleifera impairs the morphology and functions of the kidney in adult Wistar rats. Int. J. Morphol., 32(2):469-474, 2014.