Moringa oleifera Impairs the Morphology and Functions of the Kidney in Adult Wistar Rats

DOI : http://dx.doi.org/10.4067/S0717-95022014000200016
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Abdulazeez Adelaja Akinlolu; Olaide Kamal Ghazali; Oloduowo Mubarak Ameen; Seunayo Comfort Oyebanji; Gabriel Olaiya Omotoso & Bernard Ufuoma Enaibe

Summary

We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II ­ IV received 250, 500 and 750 mg/kg bodyweight of methanolic extract of Moringa oleifera respectively for twenty one days. No behavioral anomalies were observed in rats of Groups I ­ IV. Rats of Control Group I gained statistically significant increased bodyweight while rats of Groups II ­ IV experienced non-significant decreased bodyweight during experimental procedure. (P0.05). No statistical significant differences (P0.05) were observed in the analyses of the relative weights of kidneys of rats of Groups I ­ IV. Histological examinations showed normal cyto-architecture of the kidneys of rats of Group I while the Capsular spaces of the kidneys of rats of Groups II ­ IV appeared wider than those of Group I. Statistical analyses showed significant higher levels (P0.05) of Alanine and Aspartate Transaminases, and serum urea in rats of Groups II ­ IV in a non- dose-dependent manner when compared to rats of Group I. Our findings are consistent with the stated hypothesis.

KEY WORDS: Moringa oleifera; Toxicity profile; Kidney.

How to cite this article

AKINLOLU, A. A.; GHAZALI, O. K.; AMEEN, O. M.; OYEBANJI, S. C.; OMOTOSO, G. O. & ENAIBE, B. U. Moringa oleifera impairs the morphology and functions of the kidney in adult Wistar rats. Int. J. Morphol., 32(2):469-474, 2014.