General Aspects of the Proteomic Profile of Echinococcus granulosus

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Carlos Manterola; Nayely García & Claudio Rojas


The information available regarding the proteomic characteristics of E. granulosus is scarce; and it seems that the proteomic identification could improve the understanding of some biochemical and immunological characteristics of cystic echinococcosis (CE). So, the proteome of E. granulosus is still not well described yet. There are only reports of some protein sequences. The objective of this manuscript was to comment on some aspects of the existing evidence regarding studies of the proteomic profile of E. granulosus. The study of at least the cyst and its wall, the hydatid fluid and the viscera of the host are recommended. There are a series of methodologies that have been used to study the proteomic characteristics of EQ. These include SDS-PAGE, bidimensional electrophoresis combined with Western Blot, immunoassay, and mass spectrometry using MALDI-TOF techniques. A series of proteins have been identified in CE samples. Some of them, associated with immune response, gluconeogenesis, glycogenolysis and glycogenesis. On the other hand, release of exosomes to the hydatid fluid by protoescolex and germinative layer has been documented (associated virulence factors have been identified in these structures). Notwithstanding the foregoing, it requires multiple exhaustive studies in the field to better understand the characterization of the proteomic profile of E. granulosus.

KEY WORD: "Echinococcus granulosus"[Mesh]; "Echinococcus granulosus/genetics"[Mesh]; "Echinococcus granulosus/metabolism"[Mesh]; "Proteomics"[Mesh]; "Proteomics/methods"[Mesh].

How to cite this article

MANTEROLA, C.; GARCÍA, N. & ROJAS, R. General aspects of the proteomic profile of Echinococcus granulosus. Int. J. Morphol., 37(2):773-779, 2019.