Experimental model for the study of mandibular reconstruction. Options in rabbits Oryctolagus cuniculus

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Juan Pablo Alister; Carlos Veuthey; Francisca Uribe; Bélgica Vásquez; Mariano del Sol & Sergio Olate


The purpose of this study was to evaluate the surgical technique proposed for studies of resection and mandibular reconstruction in experimental models in rabbits. Seven rabbits (Orictolagus cuniculus) were used, in which the left mandibular body was resected, once the mobility of the segments was assured, reconstructed with 1.5 mm titanium osteosynthesis plate and monocortical screws of 5 mm, in the resected area a block of beta-tricalcium phosphate was stabilized and stabilized with tornbillo of 1.2 mm. The animals were sacrificed at 2 months. All animals survived the procedure, and resection and reconstruction were performed in all of them. There were no signs or symptoms of infection at the surgical site during the experiment. The average length of surgery was 68 minutes. The average weight of the animals was 3.925 g, the average weight loss was 2.03 %. No animal was euthanized for reasons of suffering. Macroscopic examination of the extracted samples showed the presence of all elements of osteosynthesis in position, as well as continuity of the bone structure almost entirely on the surface. The use of rabbits in models of maxillofacial reconstruction is a proven model due to the similarity of the reparative processes, their ease of manipulation and care. Our proposed model represents a closer alternative to the reconstructive processes in maxillofacial resective surgery, because it subjects the grafts to the forces of chewing and orofacial function.

KEY WORDS: Bone graft; Scaffold; Tissue engineering; β-TCP.

How to cite this article

LISTER, J. P.; VEUTHEY, C.; URIBE, F. ; VÁSQUEZ, B.; DEL SOL, M. & OLATE, S. Experimental model for the study of mandibular reconstruction. Options in rabbits Oryctolagus cuniculus. Int. J. Morphol., 35(3):1185-1190, 2017.