Anti-inflammatory Effect of Silymarin on Ovarian Immunohistochemical Localization of TNF-α Associated with Systemic Inflammation in Polycystic Ovarian Syndrome

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Parvin Kayedpoor; Shima Mohamadi; Latifeh Karimzadeh-Bardei & Mohammad Nabiuni


Tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6, are prominent mediators of inflammation and have been confirmed to be elevated in at least a subgroup of women with polycystic ovary syndrome (PCOS). In this study, the effects of Silymarin (SLM) on the expression TNF-α, IL-6, CRP and symptoms of PCOS were studied. In this research, PCOS was induced by injection of Estradiol Valerate. PCOS rats were divided into control and experimental groups received intraperitoneal injection SLM extract daily. After syndrome induction, ovaries were collected for histological and immunohistochemical evaluations. Serum IL-6 was detected by the ELISA kit. The results indicated the significant reduction in inflammatory markers and significant changes follicular layers thickness in the treatment group as compared with control. It can be concluded that having anti-inflammatory substances, Silymarin is effective in symptoms of this syndrome and metabolic syndrome.

KEY WORDS: Immunohistochemistry; Inflammation; Silybum Marianum extract.

How to cite this article

KAYEDPOOR, P.; MOHAMADI, S.; KARIMZADEH-BARDEI, L. & NABIUNI, M. Anti-inflammatory effect of silymarin on ovarian immunohistochemical localization of TNF-α associated with systemic inflammation in polycystic ovarian syndrome. Int. J. Morphol., 35(2):723-732, 2017.