Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Ischemia–Reperfusion Injury in Rat Ovary

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Ümit Görkem; Cihan Togrul; Izzet Sahin; Bugra Coskun; Mustafa Ozat; Tayfun Güngör1 & Engin Deveci


The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive expression of CD34. In the CAPE group the stromal vascular endothelium with weak expression of CD34 was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of CD34. In the study, Biochemical and histopathological results of CAPE treatment was considered to torsion-detorsioned the model showed a protective effect against tissue damage.

KEY WORDS: Caffeic acid phenethyl ester; Ischemia–reperfusion injury; Ovary; Rat.

How to cite this article

GÖRKEM, Ü.; TOGRUL, C.; SAHIN, I.; COSKUN, B.; OZAT, M.; GÜNGÖR, T. & DEVECI, E. Protective effect of caffeic acid phenethyl ester (cape) on ıschemia–reperfusion ınjury in rat ovary. Int. J. Morphol. 35(1):141-147, 2017.