Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats

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Marcos Kazuo Yamamoto; Moacyr Domingos Novelli; Luciana Corrêa; Suzana Cantanhede M. de Sousa & João Gualberto C. Luz


Opinions about the clinical utility of platelet-rich plasma (PRP) vary, as a large number of experimental studies have questioned its efficacy. The purpose of this study was to evaluate the effects of PRP on experimental alveolar wound healing in rats. Fifty young adult male Wistar rats were divided in control and PRP groups and submitted to extraction of the right maxillary incisor. In the PRP group, blood was collected by cardiac puncture, and the socket was filled with a PRP gel. Animals were euthanized after 1, 3, 7, 14 and 30 days. Histological and histomorphometric analyses were performed at each experimental time point. Semiquantitative histological analysis showed that the PRP group exhibited significantly more collagen-matrix deposition and less bone-matrix formation in the socket than did the control group from 7 to 30 days. Histomorphometric analyses showed that the PRP group also exhibited lower bone- tissue areas than the control group at 7 (p=0.0250) and 14 days (p<0.0001), but at 30 days, no significant difference between the groups was observed. In the present study, PRP did not enhance alveolar wound healing, and PRP-treated rats exhibited low rates of bone deposition during the intermediate phases of alveolar socket repair.

KEY WORDS: Tooth socket; Wound healing; Platelet-rich plasma; Animal experimentation.

How to cite this article

YAMAMOTO, M. K. ; NOVELLI, M. D.; CORRÊA, L.; DE SOUSA, S. C. M. & LUZ, J. G. C. Evaluation of the effect of platelet- rich plasma on alveolar wound healing in rats. Int. J. Morphol., 35(1):251-258, 2017.