Celecoxib effect in a multiresistant variant of the TA3 tumor. A histological description

DOI : http://dx.doi.org/10.4067/S0717-95022013000200005
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Carlos Rosas C.; Ignacio Roa; Mariana Sinning O.; Marcela Fuenzalida B. & David Lemus A.

Summary

In the study of cancer diverse cellular lines are in use, each with its own characteristics. One of these tumor lines is the TA3 tumor variant, multi resistant to drugs. Although diverse studies existin reference to this tumor line, there are no detailed morphological descriptions of this one, nor those that observe the effect of Celecoxib, a COX-2 tissue inhibitor. We used 18 mice divided in 3 groups that received PBS inoculation; TA3 tumor cell inoculation; cell tumor inoculation + treatment with Celecoxib (1000ppm) respectively. The mice were sacrificed and histologically processed with H & E, PAS and Arteta stain. The study revealed that tumor showed a marked heterogeneity, some areas of necrosis and central and peripheral neovascularization. Furthermore, Celecoxib significantly reduced tumor invasion in the liver (p< 0.05). Other organs did not show significant differences when compared with the treated group. The results are similar to partial descriptions realized in the past and are comparable to other tumor lines. It is estimated that the route of medication administration is critical for result interpretation. These results are important in the discussion of other research where Celecoxib is used as an antiangiogenic drug and serves as base for future research within this tumor line.

KEY WORDS: Tumor; Angiogenesis; Celecoxib.

How to cite this article

ROSAS, C. C.; ROA, I.; SINNING, O. M.; FUENZALIDA, B. M. & LEMUS, A. D. Celecoxib effect in a multiresistant variant of the TA3 tumor. A histological description. Int. J. Morphol., 31(2):392-398, 2013.