Effects of Potentilla fulgens on Tuba Uterina in Ovariectomized Rats

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Zuat Acar; U. Deger; Ü. Görkem; Cihan Togrul; E. Deveci; S. Kaya & A. Ekinci


A total of 32 Wistar rats were divided into four equal groups: (I) sham, (II) ischemia, (III) reperfusion and (IV) Potentilla fulgens. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 h of ischemia and 2 h of reperfusion were performed and no drug was given. Group IV received 400 mg/kg/day Potentilla fulgens intraperitoneally 5 days before Ischemia-reperfusion. All the parameters were observed to be significantly decreased (P<0.05) in all the experimental groups compared to the control group. In the sections of the ischemia-reperfusion group, degeneration of epithelium, dilation of blood vessels were observed. Potentilla fulgens administration reduced the morphological changes by induced I/R; in particular, infiltration, hemorrhage and vascular dilatation were decreased. Potentilla fulgens application during torsion, it plays an important role in maintaining the epithelial structure with E-cadherin expression. We suggest that PECAM-1(CD31) are a regulator of the microvascular response of the tubal mucosa.

KEY WORDS: Potentilla fulgens; Ischemia-reperfusion; Tuba uterina; Rat.

How to cite this article

ACAR, Z.; DEGER, U.; GÖRKEM, Ü; TOGRUL, C.; DEVECI, E.; KAYA, S. & EKINCI, A. Effects of Potentilla fulgens on tuba uterina in ovariectomized rats. Int. J. Morphol., 34(2):460-464, 2016.