Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats

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Mahmut Tas; Ertugrul Gök; Cenap Ekinci; Engin Deveci & Senay Deveci


SUMMARY: Bone damage and accidents, traumas can alter people's normal life, and damage the soft tissues. In this study, we aimed to investigate in calvarial defects in rats depending on the severity of cerebral contusion injury occurring in the temporal region. The rats were randomly divided into two groups: group 1 (control group), critical size cranial model with no treatment (n= 10); group 2 (14-day synthetic graft group given 7th day DEXA), critical size cranial model treated with Dexamethasone (0.05 mg/kg intramuscular injection) +Synthetic graft (n= 10) One calvarium defect of 7 mm was made in the parietal bone of each animal under general anesthesia. Calvarial defect results in dilatation of blood vessels, hemorrhage and deterioration was observed in glial fibrillary structures. Additionally, the increase in vascular endothelial growth factor expression showed a positive reaction with glial fibrillary acid protein astrocytes extensions. Apoptotic glial cells stained positive with Bcl-2. Calvarial defects caused by mild brain injury, to be induced by inflammatory cytokines, interrupting glial fibrillary degeneration by affecting the blood brain barrier is thought to promote apoptotic changes.

KEY WORDS: Calvarial defects; Rat; Cerebrum; Immunohistochemistry.

How to cite this article

TAS, M.; GOK, E.; EKINCI, C.; DEVECI, E. & DEVECI, S. Investigation of various events occurring in the brain tissue after calvarial defects in rats. Int. J. Morphol., 34(1):29-33, 2016.