Effect of Zearalenone Administrated at Late Gestation Days on Fertility of The F-1 Offspring in Swiss webster (Mus musculus)

DOI : http://dx.doi.org/10.4067/S0717-95022012000300068
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Yulia Irnidayanti

Summary

Zearalenonesolution was given to dams micesubcutaneouslyat a dose of30 mg/kg body weightat the age ofpregnancy 13 to 18 days.Control micewere given only sesameoil. Furthermore, damsmice were allowed todeliver their litter and pups were weanedon 21 days of age. The live birth index andviability of the F-1 offspring were recorded. Determination of fertility of the F-1 offspring were undertaken by mating interlitters. On days 18 of gestation, the F-1 offspring were killed by cervical dislocation. The observation was performed on the number of live or dead fetus, embryo resorption, the number of implantation and the percentage of gestation loss. The result revealed that administration of zearalenone on days 13 to 18 of gestation caused a significant decreasein the number of implantation as the result of mating between control male with treated female and treated male with tretaed female of the F-1 offspring. It could be concluded that in the F-1 offspring, zearalenone interfered the process of ovarian develoment, stimulated the differentation of the uterus, decreased the fertility of the female and the effect of zearalenon was more persistent in the female than in the male.

KEY WORDS: Zearalenone; Fertilitas indeks; Gestation indeks; Number of implantation; Persistent.

How to cite this article

IRNIDAYANTI, Y. Effect of zearalenone administrated at late gestation days on fertility of the F-1 offspring in Swiss webster (Mus musculus). Int. J. Morphol., 30(3):1197-1202, 2012.