Histopathological Analysis of the Articular Cartilage Exposed to Methylprednisolone, Ropivacaine and Hyaluronic Acid in an Animal Model of Osteoarthrosis

DOI : http://dx.doi.org/10.4067/S0717-95022014000400013
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Ranmel Bustos Latabán; Iván Alberto Marino Martínez; Víktor Javier Romero Díaz; Oscar Fernando Mendoza Lemus; Jorge Lara Arias & Santiago De La Garza Castro


Osteoarthritis is a musculoskeletal condition with a high prevalence, increasing with the aging of population. The intraarticular infiltration of substances to relieve the symptoms of osteoarthritis is a common practice in medical practice. Although symptoms improved with the infiltration of local anesthetics, corticosteroids and supplements, it is still uncertain what effect these substances have on the integrity of articular cartilage. This study explores the macroscopic and histological effects of infiltration of Ropivacaine, Methylprednisolone and Hyaluronic Acid on articular cartilage in a model of chemical osteoarthritis in rabbits (n=24). Our results indicate that in the infiltrated groups with Methylprednisolone (n=8) and Ropivacaine (n=8) the structure of articular cartilage present more severe alterations with respect to its control group and an important decrease in the synthesis of extracellular matrix. In-group infiltrated with hyaluronic acid (n=8), macroscopic and histological changes of articular cartilage improved with respect to its control group, presenting a normal structure and normal extracellular matrix synthesis.

KEY WORDS: Intraarticular Infiltration; Articular Cartilage; Osteoarthritis.

How to cite this article

BUSTOS, L. R.; MARINO, M. I. A.; ROMERO, D. V. J.; MENDOZA, L. O. F.; LARA, A. J. & DE LA GARZA, C. S. Histopathological analysis of the articular cartilage exposed to methylprednisolone, ropivacaine and hyaluronic acid in an animal model of osteoarthrosis. Int. J. Morphol., 32(4):1199-1206, 2014.