Molecular Markers and Image Biomarkers. Importance in the Therapeutic Advance of Intraaxial Brain Tumors

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Ulises Guajardo-Hernández; Federico Geisse Martínez; Luis Martí-Bonmatí; Roger Gejman Enriquez & David Rojas Zalazar


The classification of primary tumors of the Central Nervous System (CNS) has its origin in the morphological description whose histopathological analysis has allowed to identify the cell line involved in these tumors and obtain the recognition of certain characteristics of these lesions and their clinical evolution. The molecular study has come to complement the initial diagnosis allowing to recognize entities that are not distinguishable in another way and that have varied the concepts and definitions of various pathological entities modifying the vi- sible horizon of these diseases. The role of Magnetic Resonance (MR) images in the management of intraaxial tumors can be broadly divided into the diagnosis and classification of tumors, treatment planning and subsequent treatment. The present article summarizes the epidemiologic evidence related to the classification of primary tumors of the CNS with molecular markers and MR imaging biomarkers.

KEY WORDS: Brain tumor, MR images; Biomarkers.

How to cite this article

GUAJARDO-HERNÁNDEZ, U.; GEISSE, M. F.; MARTÍ- BONMATÍ, L.; GEJMAN. E. R. & ROJAS, Z. D. Molecular markers and image biomarkers. Importance in the therapeutic advance of intraaxial brain tumors. Int. J. Morphol., 39(2):601- 606, 2021.