Preservation of Histology by Phenol-Based Fixative: Mini Review of Recent Findings

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S. M. Niazur Rahman; Tanbira Alam & Nazmun Nahar Alam


In surgical and anatomical training, use of cadaver remains the most ideal technique. Standard formaldehyde solution preserves cadaveric tissues for an extended period comparing to the unfixed tissues. However, it fails to retain the natural texture, color, and biomechanical features. Phenol based soft embalming methods were developed to maintain these properties, while simultaneously decreasing the biohazard risk. Soft embalming techniques have made the bodies more ‘lifelike’ and wellfitted for training. Though phenol fixation displays rewarding morphological maintenance, we have scanty evidences on the histological preservation. This mini review primarily discussed the latest reports regarding the effect of phenol-based fixation on the tissue histology. Published literatures revealed phenol-based fixation displayed comparable histological preservation to that ofgold standard paraformaldehyde-based solution. It was concluded that phenol-based solution is an excellent fixative used to preserve tissues for microscopic analysis.

KEY WORDS: Phenol; Embalming solution; Soft embalming; Histological fixative; Microscopy.

How to cite this article

RAHMAN, S. M. N.; ALAM, T. & ALAM, N. N. Preservation of histology by phenol-based fixative: Mini review of recent findings. Int. J. Morphol., 39(1):50-56, 2021.