Ricardo Henríquez;Víctor Armijo; Ana Merino; Felipe Nuñez; Elena Marín-Cascales; JacoboA Rubio-Arias & Carlos Vargas

The objective of the present study is to analyze the effects of gestational voluntary locomotor activity, as a type of physical training, on the morphology of the offspring ́s heart pump, in a murine model of the CF-1 strain. Twelve (12) pregnant females were randomly divided in a control group and a group performing voluntary locomotor activity, by accessing an activity wheel during the first 12 days of gestation. Cardiac morphology was evaluated using cross sections, measuring thickness and area of the walls of the right ventricle, left ventricle, and septum, both in absolute values and values relative to the individual's body mass. It was observed that the body mass of the control pups (CG) was significantly higher than those of the group whose females accessed the activity wheel (GE) (p <0.01). Differences were observed only in absolute values of thickness and myocardial areas of the right ventricle, between the GE and GC group (p <0.05). However, when evaluating the thickness and areas relative to body mass, it was observed that the offspring of the GE group presented thicknesses and areas significantly larger than those in the GC group (p <0.01). In conclusion, gestational physical activity alters the morphological development of the heart pump in CF-1 mice, significantly increasing the thickness and area of the myocardial walls in relation to offspring total body mass.

HENRÍQUEZ, R.; ARMIJO, V.; MERINO, A.; NUÑEZ, F.; MARÍN-CASCALES, E.; RUBIO-ARIAS, J. & VARGAS, C. Effects of gestational voluntary locomotor activity on cardiac morphology in murine offspring. Int. J. Morphol., 39(1):95-101, 2021.