Ultrastructural Effects of the Propineb on Brain of Fetuses During Rat Pregnancy

DOI : http://dx.doi.org/10.4067/S0717-95022014000400054
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Ekinci, C.; Tahaoglu, A. E.; Yavuz, D; Deveci, E.; Aktas, A.; Yilmaz, T.; Yumusak, Ö. & Yükselmis, O.


Propineb is a fungicide with a propylene-bis-dithiocarbamate structure. Pregnant Wistar rats were exposed to 400 ppm propineb concentrations in 5 ml distilled water, 5 days per week until the end of pregnancy. The rats were treated with propineb for 16 days and the brains of litter rats were sacrificed at first day of birth after which their brains were collected. Ultrastructural examination of the brains of the fetuses and propineb-treated pregnant females revealed a variety of histopathological effects. We suggest that mitochondrial damage may be an effective factor for neuron necrosis. These results supported the proposal that the exposure to fungicides such as propineb and to other naturally occurring compounds which inhibit mitochondrial function, may contribute to Parkinson's disease development.

KEY WORDS: Propineb; Electron microscopy; Neonatal rats; Brain.

How to cite this article

EKINCI, C.; TAHAOGLU, A. E.; YAVUZ, D.; DEVECI, E.; AKTAS, A.; YILMAZ, T.; YUMUSAK, Ö. & YÜKSELMIS, O. Ultrastructural effects of the propineb on brain of fetuses during rat pregnancy. Int. J. Morphol., 32(4):1467-1471, 2014.