Antiangiogenic Effect of Triamcinolone Associated with Lidocaine with Epinephrine for Dental use in Chicken Chorioallantoic Membrane

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Marcelo Mardones M.; Rodrigo Bravo A.; Luis A. Córdova; Josefina Santana L.; Claudio Zamorano C. & David Lemus A.


Angiogenesis is defined as the process through which new blood vessels form from previously existing vessels. Several inflammatory, infectious, ischemic, immunological and malignant disorders are caused by the lack of adequate angiogenesis balance. In the maxillofacial area, there are invasive benign neoplastic pathologies with a strong angiogenic component, which determines aggressive behavior and growth. Studies in the literature are scarce regarding treatment of these conditions based on angiogenesis control. Currently, the protocol used to treat these maxillofacial benign neoplastic lesions, was developed in 1994 by Terry & Jacoway and has a strong angiogenic component. Consequently lesions are treated via intra-lesion administration of triamcinolone 10 mg / mL, a solution used in dental local anesthetic, such as lidocaine 2 %, in conjunction with epinephrine at a concentration of 1:200,000. The objective of this study was to compare the antiangiogenic effect of this protocol in chicken chorioallantoic membrane (CAM) without the use of local anesthetic. The results of the antiangiogenic effect in the CAM obtained in this study concluded that the effect of the suspension of triamcinolone associated to lidocaine with epinephrine, is similar to the suspension of triamcinolone without associating local anesthetics. Furthermore, it was determined that suspensions of triamcinolone without local anesthetic, and those associated to local anesthetic with, and without vasoconstrictor have a strong antiangiogenic effect in CAM compared to the control group.

KEY WORDS: Angiogenesis; Chorioallantoic membrane; Triamcinolone; Epinephrine.

How to cite this article

MARDONES, M. M.; BRAVO, A. R.; CÓRDOVA, L. A.; SANTANA, L. J.; ZAMORANO, C. C. & LEMUS, A. D. Antiangiogenic effect of triamcinolone associated with lidocaine with epinephrine for dental use in chicken chorioallantoic membrane. Int. J. Morphol., 37(1):344-348, 2019.