Does Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat?

Tweet about this on TwitterShare on FacebookEmail this to someoneShare on Google+

Naser A. ElSawy; Abdullah G Alkushi; Wardah Abdullah Mohammed Alasmari; Mustafa M. Sinna; Eslam A. Header; Mohammad A. Elmadbouly & Ashraf Mohamed Elsayed Ali Sakran


Origanum vulgare Linn has traditionally been used as a diuretic and antispasmodic. Therefore, we investigated the active extract of Origanum vulgare for possible andrological effect and preventive effects against testicular damage using ethylene glycol rat model of testicular damage, to rationalize its medicinal use. Male Wistar rats received lithogenic treatment comprising of 0.75 % ethylene glycol injection twice with one day interval, then in drinking water, active extract of Origanum vulgare treatment (20 mg/kg) was given for 3 weeks to prevent toxic damage including loss of body weight gain and appetite, Following oral administration of EGME, a rapid decrease in testis weight associated with testicular cell damage was observed. Origanum vulgare treatment (20 mg/kg) prevented as well as reversed toxic changes including loss of body weight gain.

KEY WORDS: Origanum vulgare; Ethylene glycol; Testicular damage.

How to cite this article

ELSAWY, N. A.; ALKUSHI, A. G.; ALASMARI, W. A. M.; SINNA, M. M.; HEADER, E. A.; ELMADBOULY, M. A. & SAKRAN, A. M. E. A. Does oregano protect against testicular toxicity produced by ethylene glycol in adult male albino rat? Int. J. Morphol., 37(1):358-362, 2019.