Effect of Cigarette Smoking on the Structure of Hepatocytes: TEM Study.

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Khairat A. Battah; Darwish H. Badran & Ziad A. Shraideh


The liver is one of the major organs that is indirectly affected by cigarette smoke. The aim of this project is to define the histologic and ultrastructural changes in normal liver cells after exposing animals to cigarette smoke. Thirty albino rats were exposed to cigarette smoke for 90 days, followed by morphologic examination of their livers under light microscope and electron microscope. The liver cells of cigarette smoke exposed rats showed mild swelling with increased eosinophilia. Ultrastructural examination of these cells demonstrated cytoplasm with highly proliferated and crowded mitochondria. There were many electron dense mitochondria. These mitochondria were pleomorphic in shape compared to mitochondrias of control rats. Also, loss of mitochondrial cristae and widening of the intermembranous space was noticed. It is concluded that smoking exerts cellular damage and oxidative stress on normal liver cells resulting in ultrastructural changes.

KEY WORDS: Liver; Smoking; Mitochondria; Ultrastructure.

How to cite this article

BATTAH, K. A.; BADRAN, D. H. & SHRAIDEH, Z. A. Effect of cigarette smoking on the structure of hepatocytes: TEM Study. Int. J. Morphol., 34(4):1239-1244, 2016.