In this study we examined the effects histopathologic and immunohistochemical of xylene inhalation in rats by using light microscopy. Adult wistar albino rats were used in this study. Eight rats were in control group and 8 rats were in the experimen- tal group. The experimental group was exposed to 300 ppm formaldehyde 3–5 min/day, 5 days/week for 8 weeks. The lining epithelium ofrespiratorymucosashowedalossofciliatedcellswithmetaplasiaofgobletcells,hyperplasiaofsquamouscellsandedema, inflamation in sub epithelial area). In the group treated xylene. Disruption of cell-cell contact was observed. Weak expression of E-cadherin was observed between cells. The vascular endothelium of capillaries and venoles showed intense immunostaining for VEGF.
KEY WORDS: Xylene; Vascular endothelial growth factor; E-Cadherin; Respiratory mucosa.