Use of Anabolic Steroid Altered the Liver Morphology of Rats

DOI : http://dx.doi.org/10.4067/S0717-95022014000300002
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Valéria Simões Tanasov; Walter Krause Neto; Leandro Gonçalves; Laura Beatriz Mesiano Maifrino; Romeu Rodrigues de Sousa & Eliane Florencio Gama.

Summary

The aim of this research was to investigate the effect of testosterone propionate administration in the liver of rats. The rats were divided in the following groups: Initial control (SC), Aged control (SE) and Anabolic group (SA). Testosterone propionate was administered three times per week during 16 weeks. Using morphoquantitative techniques, we quantified the volume densities of lobular and non-lobular parenchyma, area and number of nuclei of hepatocytes. The data were analyzed statistically using mean and standard deviation, ANOVA one-way and level of significance about p0.05. Our results showed an increase in capillaries, perisinusoidal spaces and biliary ducts in SE group compared to SC. SA group showed a decrease in hepatic cells, non-lobular volume density and hepatocytes nuclei area, but also an increase in capillaries, perisinusoidal spaces, biliary ducts, number of hepatocytes and non-hepatocyte nuclei compared to SC. We conclude that a direct toxicity may have occurred, with consequent loss of the cells.

KEY WORDS: Aging; Testosterone proprionate; Hepatic tissue; Animals.

How to cite this article

TANASOV, V. S.; NETO, W. K.; GONÇALVES, L.; MAIFRINO, L. B. M.; DE SOUSA, R. R. & GAMA, E. F. Use of anabolic steroid altered the liver morphology of rats. Int. J. Morphol., 32(3):756-760, 2014.